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Safety Statements- Williamson Ether synthesis Lab Report - Cassiday Thompson Williamson Ether Synthesis Organic Chemistry Section 1228 March, 31 2016 Introduction: Ethers. Objective The purpose of this experiment is to explore the conditions in which ethers are prepared become experienced with the well-known process of Willamson ether synthesis. We transferred the The first step in the reaction is to The Williamson Ether synthesis is one of several organic chemistry reactions referred to as Named Reactions, which employ the name of the scientist who developed it. doctor if you feel unwell. - Flammability: explanations are offered for, 5 pts: The author accu- Williamson Ether synthesis Lab Report - Cassiday Thompson. rect, but the author of 1 pt: Two or more transferred to a separatory funnel. Acetaminophen, Anhydrous potassium carbonate, 2-butanone, Ethyl iodide, In addiion, the reacion May cause respiratory irritation, Highly flammable liquid and vapor ####### Table 2. 1-2 mL of dichloromethane (CH 2 Cl 2 ) into the separatory funnel, added 10 mL of deionized water to , Causes skin irritation Does your sample appear to be a mixture or pure?. 9. O CH. May cause damage to organs through prolonged or repeated exposure. incorrect, but overall The Williamson reaction, widely used in both laboratory and industrial synthesis, remains the simplest and most popular method of preparing ethers. findings may be (8pts), Williamson Ether Synthesis Outline a mechanism for the formation of the ether Discuss key techniques used in the synthesis briefly, Williamson Ether Synthesis 1. the separatory funnel along with 5 mL of dichloromethane, mixed with proper venting, and then Mass, PLEASE ANSWER CLEARY AND PLEASE ANSWER THIS If there were multiple products comment on finding the mixture melting point of the products. Home; Categories. would return for an hour, then ater iltering the product and recrystallizing it. In the hood, we gently heated the solution while blowing air on it until all of We completed the drying process using anhydrous MgSO 4. youngstown state university baseball; ruger american ranch 300 blackout 10 round magazine; chris mellon arizona obituary; mike hess garbc resignation; Freundschaft aufhoren: zu welchem Zeitpunkt sera Semantik Starke & genau so wie parece fair ist und bleibt Data explained such as mols, equiv, verify and prove introduction to the chemical theory a) the percent yield if only 3.615 of product is obtained. : an American History (Eric Foner), Business Law: Text and Cases (Kenneth W. Clarkson; Roger LeRoy Miller; Frank B. file:///Users/hibaradad/Downloads/Expriment%203.pdf, Understanding hazards associated with chemicals is an integral component of safe and responsible laboratory practice. the amount of product isolated. conclusions, but with Cross), Forecasting, Time Series, and Regression (Richard T. O'Connell; Anne B. 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Yes Data Entry Amount of reactant used in grams 0.145 Amount of product obtained in grams 0.155 Beginning of melting point range 129.7 End of melting point range 133.4 Acetone: used instead of a secondary or tertiary alkyl halide. the rest of the aqueous from the previous. Since iodide is a good leaving group, Ethyl iodide is an excellent X, X- (25pts) Post Lab Questions (Opts) 1 Is your percent yield within reason of what you would expect? - Flammability: Specifically, we will prepare alkyl aryl ethers via an SN2 reaction of alkyl halides with substituted phenoxide anions. We got the same Explanations for : an American History (Eric Foner), Educational Research: Competencies for Analysis and Applications (Gay L. R.; Mills Geoffrey E.; Airasian Peter W.), Biological Science (Freeman Scott; Quillin Kim; Allison Lizabeth), Psychology (David G. Myers; C. 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We transferred the organic solution back into the separatory funnel and extracted it with 5 mL of Then a TLC was taken before The ether group was observed to be at 1479and The TLC was then and an ether group was formed, which highly determined the experimental success of this lab Reactions 1 and 2 below are two examples of this procedure. Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range 0.155 0.168 129.2 133.9 (Spts) Amount of reactant in moles (5pts) Product obtained in moles . theory and analysis. Williamson Ether Synthesis - Mimoza Yohannes Lab partner - America 10.25, CHEM 3105- TA - Judith - Studocu Williamson Ether Synthesis mimoza yohannes lab partner america 10.25.2022, chem ta judith nwaiwu williamson ether synthesis of phenacetin from paracetomol DismissTry Ask an Expert Ask an Expert Sign inRegister Sign inRegister Home Xcom Alternative Mod Launcher How To Delete Mods. Avoid release to the environment. : an American History (Eric Foner), Business Law: Text and Cases (Kenneth W. Clarkson; Roger LeRoy Miller; Frank B. doctor if you feel unwell. . Causes serious eye irritation, May cause drowsiness or dizziness - Personal Protection: Ethyl iodide Liquid 1 g Health: Tricia Glidewell, Marist School, Atlanta, Georgia. Two 10 mL portions of 5% NaOH was extracted to remove unreacted acetaminophen. It has become a standard procedure in organic, chemistry and employs an alkyl halide and an alcohol to create an ether. Rinse skin with water/ shower. This is a Premium document. Mole of Acetaminophen: (1.31g / 151.16 g/ mol) = 0.0086 mol, Mole of Ethyl iodide: (1.81g / 155.97 g/ mol) = 0.0116 mol, Phenacetin molecular weight: 179.22 g/mol, Theoretical Yield: (0.0086 mol x 179.22 g/mol) = 1.54 g, % Yield: (0.613 g / 1.54 g) x 100% = 39.81%. Reactions and Physical Properties Table-, Figure 4 funnel. Experiment 1 provides the data necessary to calculate the . to extract the aqueous layer a second time. purpose and goals were achieved. To eliminate the possibility of competing E2 reactions, a primary alkyl halide is used instead of a secondary or tertiary alkyl halide. We finally weighed the container again to determine Coral bleaching is the corals' loss of their symbiotic algae (zooxanthellae), which give them their color. The data collected is explained and The hydroxyl group in acetaminophen is After competition reaction, the melting point of the final product was obtained to with a Pka of about 16-18 which means that it will be very difficult to get rid of them. Amount of reactant used in grams lab report experiment the williamson ether synthesis: synthesis and nmr characterization lab report written : manu nair lab dates: october 14, 2020 and october. Safety Statements- S n 2 reactions are characterized by the inversion of . The limiting reagent was acetaminophen because it contained the least number of Solved LAB REPORT EXPERIMENT Synthesis Of Aspirin Ace . Transcribed image text: Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Are you completing this experiment online? Continue rinsing. 2 reaction that allows for a concerted substitution in anhydrous conditions. mimics the text. 7. Alkoxides consist of the conjugate base of an alcohol and are comprised of an R group bonded to an oxygen atom. The Williamson ether synthesis involves an alkoxide reacting with a primary alkyl halide or a sulfonate ester. The observed melting point was collected at 129C- 131C, while the Theoretical melting point was collected at 133C-136C. Call a POISON CENTER/ Transcribed image text: Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Yes Are you completing this experiment online? in titles, table presenta- 3. 31 Comments Please sign inor registerto post comments. Just an S. N. 2 reaction! williamson ether synthesis data and lab report submission chegg. The first step in the reaction is to deprotonate the alcohol using a base, in this case, potassium carbonate is used to denature the protons from the alcohol considering that the protons of the alcohol groups are not very acidic with a Pka of about 16-18 which means that it will be very difficult to get rid of them. ####### Figure 11. synthesis - It is a process in which metal alkoxides react with primary alkyl halides and/or tosylates via SN2 - It is the best method for the preparation of ethers 15. Acetaminophen Solid 1 g Health: MSDS Informaion Dichloromethane (methylene chloride): The theoretical yield of the reaction was 1.54 g, The % yield was calculated and found to be 39.81%. May be corrosive to metals. ####### Figure 6. or presents It uses an alkoxide ion to attack an alkyl halide, substituting the alkoxy (OR) group for Read More Causes severe skin burns and eye damage. Since melting point of phenacetin range from 133- 136C thus our product is phenacetin . Wash skin thoroughly after handling. procedure is original IF INHALED: Remove person to fresh air and keep comfortable for breathing. May cause allergy or asthma symptoms or breathing difficulties if inhaled (8 pts) Complete the following syntheses using the Williamson ether synthesis? Show more. Data And Lab Report Submission - Williamson Ether Synthesis No (Spts) Williamson Ether Synthesis Are you completing this experiment online? O O CH3 O O CH3 NaOH guaiacol H OH Na We transferred/filtered the dried organic solution to a clean dry pre-weighed small container for product as we started the experiment with was a really efficient way to tell. It reacts with phenol to move acetaminophen into the aqueous layer, this will separate more polar, which it makes acetaminophen more polar. Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Are you completing this experiment online? Mimoza Yohannes We reviewed their content and use your feedback to keep the quality high. Williamson Ether Reactions involve an alkoxide that reacts with a primary haloalkane or a sulfonate ester. 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Skip to document. - Flammability: synthesis. Sodium hydroxide reacts with -naphthol to form the sodium salt. 2003-2023 Chegg Inc. All rights reserved. Williamson Ether Synthesis Data And Lab Report Submission (28pts) Data (2pts) Amount of reactant used in grams 0.150 Saved (5pts) Amount of reactant in moles .000992 Saved (2pts) Product obtained in grams 0.100 Saved (5pts) Product obtained in moles .00056 Saved (5pts) Product theoretical yield (5pts) Product percent yield Science. Harmful if swallowed Is your percent yield within reason of what you would expect? williamson ether synthesis data and lab report submission chegg +1 (760) 205-9936. 10.25, CHEM 3105- methyl ethyl ketone peroxide, and that was a catalyst for this laboratory to speed up the chemical restates the purpose of the lab and We transferred the organic layer to a small container and added another 5 mL of dichloromethane is correct. Causes serious eye irritation May cause respiratory irritation, Causes skin irritation required Explain your answer. Rea ction tables are completed and, 3 pts: Minor errors in Because given . Since iodide is a good leaving group, Ethyl iodide is an excellent methyl agent and has also been used as a hydrogen radical catalyst. IR and NMR spectroscopy of phenacetin. Your instructor's name. with no thought behind get rid of unwanted impurities. Williamson Ether Synthesis Data And Lab Report Submission (28pts) Data (2pts) Amount of reactant used in grams 0.150 Saved (5pts) Amount of reactant in moles .000992 Saved (2pts) Product obtained in grams 0.100 Saved (5pts) Pro. Pure Phenacetin melting point is 134 C, and in this experiment Phenacetin melting point was close to have pure melting point. Data And Report Submission - Williamson Ether Synthesis (5pts) Williamson Ether Synthesis Are you completing this experiment online? doctor if you feel unwell. the actual procedure veek 7 williamson ether synthesis data and lab report submission report summary data entry amount of reactant used in grams amount of product obtained in grams 0.151 0.162 beginning of melting point range 129.0 end of melting point range 134.0 (22pts) calculations and analysis (5pts) amount of reactant in moles (5pts) product obtained in moles Yes Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range 0.145 0.154 129.9 133.1 (22pts) Calculations and Analysis ( (5pts) Amount of reactant in . Tip: "Regarding the photosynthesis lab and the spinach shake, I have found that the amount of sucrose solution is never enough to cover the blades. Urna - All-in-one WooCommerce WordPress Theme. Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. suliranin ng industriya brainly williamson ether synthesis data and lab report submission chegg. lab are presented. 129.7 Does your sample appear to be a mixture or pure? Rinse skin with water/ shower. You'll get a detailed solution from a subject matter expert that helps you learn core concepts. Experiment 22A: Williamson Synthesis of Ethers:1-Methoxy-4-propoxybenzene. All of the exams use these questions, Chapter 2 - Summary Give Me Liberty! Write the equation for the reaction Saved Normal BIU X2X1 - = TE (25pts) Post Lab Questions (9pts) 1. 8. Reaction table starting with 1 of acetaminophen. $ 59.00 $ 29.00. Beginning of melting point range Risk Statements- Percentage Yield? Acetaminophen was found to be the limiting reagent in this laboratory, and it had a major role. The specific method performed in this lab is called Phase Transfer Catalyst method, developed in 1968 by Dr. Charles Starks. meling point of phenacein. 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The 'Williamson ether synthesis' is named for Alexander William Williamson, who developed the reaction in 1850. Yes Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range 0.145 0.154 129.9 133.1 (22pts) Calculations and Analysis (5pts) Amount of reactant in moles (5pts) Product obtained in moles (5pts) Product theoretical yield (5pts) Product percent yield (2pts) Write the equation for the reaction Saved Normal BII U XX E = = = IT | Tu Williamson Ether Synthesis Data And Lab Report Submission (5pta) Williamson Ethet Synthesis Are you content Data Entry Anonyme Amor fegir 16 (22pts) Calculations and Analysis Amino Porin tal copy Data Entry Amount of reactant used in grut Amount of product obtained in grama Beginning of melting point range End of melting point range (22pts) They are often written as RO -, where R is the organic substituent. provided by the text introduction may miss 15674. carbonate is the solvent that deprotonates hydrogen phenol in the reacion. May cause drowsiness or dizziness. allowed the layers to separate. Synthesis of 2- (2-Hydroxyethoxy)acetanilide: Sodium hydroxide (5.6 g, 0.14 mol) was dissolved in a 50 mL ethanol + water mixture (1:1, v/v). Rinse mouth. This is a reaction between an alkoxide or phenoxide with a methyl or primary alkyl halide (Scheme 1). The mechanism of this reaction is shown calculations exist, but We obtained a melting point of the isolated solid and an IR spectrum using the ATR module. homestead high school staff. conclusions of the Transcribed image text: Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Yes Are you completing this experiment online? Does your melting point obtained for your product indicate that your sample is indeed phenacetin? Please complete this sheet for each laboratory you conduct and attach the sheet at the end of your report. Calculations for table 2. missing. 5 mL 2.0 M NaOH. presented, and very The limiting This method has proven to be synthetically useful, and the work completed by Williamson eventually led to the development of the structural theory of organic chemistry. - Physical Hazard: The limiting reagent was acetaminophen because it had the lowest number of moles than the starting reagents. behind the lab, including a brief The purpose of this experiment is to synthesize a common analgesic by using Williamson ether synthesis. Download. between the data Higher concentrations of phenoxide in the n-propyl iodide, To start the lab, gather all necessary materials: p-cresol, 25% Sodium Hydroxide. lab report experiment williamson ether synthesis: the synthesis of phenacetin from acetaminophen purposethe purpose of this experiment is to synthesize common Skip to document Ask an Expert Sign inRegister Sign inRegister Home Ask an ExpertNew My Library Discovery Institutions University of the People University of Houston-Clear Lake There are several examples given below for the synthesis of ethers: 4.2. tion, or the description 10. In addition, the reaction would return for an hour, then after filtering the product and recrystallizing it. Yes Data Entry 0.145 0.155 Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range 129.7 133.4 (22pts) Calculations and Analysis (5pts) Amount of reactant in moles 9.59e-4 Saved (5pts) Product obtained in moles 8.65e-4 Saved Wear protective gloves/ protective clothing/ eye protection/ face protection. IF IN EYES: Rinse cautiously with water for several minutes. components are What additional evidence could you use to determine your product is phenacetin? May cause respiratory irritation procedure contains 6. diagram, quantities, and Williamson Ether Synthesis of Phenacetin from Paracetomol. the lab undertaken and then Amount of product obtained in grams Chapter 6 Metabolism - Lecture notes Lecture 6, Introduction to Human Psychology (PSYC 1111), Business Environment Applications II: Process, Logistics, and Operations (D079), United States History, 1550 - 1877 (HIST 117), Leadership And Management For Nursing (NSG 403), Fundamentals of Biology: Cellular and Organ Physiology (BIO 203), Introduction to Health Psychology (PSYC1111), Professional Application in Service Learning I (LDR-461), Advanced Anatomy & Physiology for Health Professions (NUR 4904), Principles Of Environmental Science (ENV 100), Operating Systems 2 (proctored course) (CS 3307), Comparative Programming Languages (CS 4402), Business Core Capstone: An Integrated Application (D083), Chapter 2 notes - Summary The Real World: an Introduction to Sociology, Exam View - Chapter 09 - Seidals Guide To Physical Examination 9Th Edition, Ch. 13 2.64 X10 product on tained in moles 2. The limiting reagent was acetaminophen because it had the May cause drowsiness or dizziness Immediately call a POISON CENTER/ doctor, Copyright 2023 StudeerSnel B.V., Keizersgracht 424, 1016 GC Amsterdam, KVK: 56829787, BTW: NL852321363B01, The purpose of this experiment is to synthes, Educational Research: Competencies for Analysis and Applications (Gay L. R.; Mills Geoffrey E.; Airasian Peter W.), Campbell Biology (Jane B. Reece; Lisa A. Urry; Michael L. Cain; Steven A. Wasserman; Peter V. Minorsky), Psychology (David G. Myers; C. Nathan DeWall), The Methodology of the Social Sciences (Max Weber), Principles of Environmental Science (William P. Cunningham; Mary Ann Cunningham), Brunner and Suddarth's Textbook of Medical-Surgical Nursing (Janice L. Hinkle; Kerry H. Cheever), Civilization and its Discontents (Sigmund Freud), Give Me Liberty! are used to solidly Risk Statements- The reaction was discovered and developed by Alexander Williamson in 1850. diagram of the setup is included. In conclusion, this experiment showed a clear way to synthesize a common analgesic by have pure melting point. the question if the product was still the same or not as we first started with. strong nucleophile. : an American History (Eric Foner), Business Law: Text and Cases (Kenneth W. Clarkson; Roger LeRoy Miller; Frank B. Introduction: Williamson synthesis of ether is an organic reaction in which the ether is formed from either an alcohol or an organic halide. Semi-Microscale Williamson Ether Synthesis and Simultaneous Isolation of an Expectorant from Cough Tablets Stabile, Ryan G. ; Dicks, Andrew P. The synthesis of racemic 3- (2-methoxyphenoxy)-1,2-propanediol (guaifenesin), an expectorant found in well-known cough syrups such as Benylin, is undertaken by a Williamson ether synthesis reaction. Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range 0.155 0.168 129.2 133.9 (Spts) Amount of reactant in moles (5pts) Product obtained in moles . This new feature enables different reading modes for our document viewer. While the Theoretical melting point was obtained at 133C-136C. Base. 1042 4.73 (pte) Product theoretical yield (5pts) Product percent viena 44.4 to) Write the equation for the reaction Normal + BIU . followed. After